Biomechanics Lab, BME, OUS

Introduction

Mechanical behavior of living materials is scientifically very interesting, the understanding of which is of vital importance in many branches of medicine, from sports science to the design of medical devices. Materials such as bone, muscle, tendon/ligament, blood vessel, heart have intriguing and unique characteristics. These tissues change their morphology, structure and function so as to adapt to the mechanical environment. For example, heart and arteries are thickened by increase in arterial pressure, and are dilated by increase in blood flow. Bone, muscle, and tendon/ligament are weakened when force is reduced. The understanding of such phenomena is very important not only to know the mechanisms of the pathophysiology of living systems but also to develop techniques and methods for clinical diagnosis, prevention of diseases, and medical therapy of, for example, cardiovascular diseases, osteoporosis, and sports injury. The aim of OUS Biomechanics Laboratory is to study biomechanical factors leading to the functional adaptation and diseases of living systems from macroscopic to microscopic levels.

Researches

Measurement of the mechanical behavior of living tissues and biomaterials:

Tendons & ligaments
Blood vessels
Heart

Analyses of adaptation of living tissues to mechanical stress and genesis of diseases:

Osteoporosis
Sports injuries like tendon / ligament rupture
Atherosclerosis and hypertension
Cardiac hypertrophy

Application to clinical diagnosis & medical treatment

Members

Professor Takeru Naiki, Building No.27, 3rd floor, 304,
　tnaiki＠bme．ous．ac．jp

Room & Devices

Papers (Last five years)
【Major Publications】

E. Yamamoto, D. Kogawa, S. Tokura and K. Hayashi, Biomechanical response of collagen fascicles to restressing after stress deprivation during culture, J. Biomechanics, 40(9), 2063-2070, 2007
K. Hayashi and T. Sugimoto, Biomechanical response of arterial wall to DOCA-salt hypertension in growing and middle- aged rats, J.Biomechanics, 40(7), 1583-1593, 2007
G.V. Guinea, J.M. Atienza, M. Elices, P. Aragoncille and K.Hayashi, Thermo-mechanical behavior of human carotid arteries in the passive state, Am. J. Physiology 288(6), H2940-H2945, 2005
A. Terrier, J. Miyagaki, H. Fujie, K. Hayashi and L. Rakotomanana, Delay of intracortical bone remodeling following a stress change: A theoretical and experimental study, Clinical Biomechanics, 20(9), 998-1006, 2005
M.A. Zulliger, P. Fridez, K. Hayashi and N. Stergiopulos, A strain energy function for arteries accounting for wall composition and structure, J. Biomechanics, 37(7), 989-1000, 2004
S. Kuriki, A. Hayashi, Y. Hirata, T. Naiki and K.Kawahara, High Tc SQUID magnetometer for measurements of heat-rate signal of small animals, Chinese Journal of Physics, 42(4), 501-507, 2004
H.Miyazaki, K. Hayashi and Y. Hasegawa, Tensile properties of fibroblasts and vascular smooth muscle cells, Biorheology, 40(1-3), 207-212, 2003

【International Poceedings】

Y. Mizutani, T. Naiki, K. Kawahara, Contractile function in hypertrophied myocardial cells: Contractile force measurements in myocardial cells using carbon fibers, IFMBE proceedings Vol.12, CD-ROM, 2005
T. Naiki, Y.Mizutani, K. Kawahara, Active tension in hypertrophied myocardial cells, Proceedings of the Second Japan-Switzerland Workshop on Biomechanics, 102, 2005
Y. Mizutani, T. Naiki, K. Kawahara, Contractile function in hypertrophied myocardial cells, Proceedings of the International Federation for Medical and Biological Engineering, 2005.

【Books】

K. Hayashi, Tensile properties and local stiffness of cells, Mechanics of Biological Tissue, Ed. by G.A. Holzapfel and R.W. Ogden, Springer-Verlag, Berlin, Heidelberg, 137-152, 2006
K. Hayashi et al., Encyclopedia of Medical Devices and Instrumentation, John Wiley & Sons, Hoboken, New Jersey, 2006.
K. Hayashi et al., Biomechanics of Soft Tissue in Cardiovascular Systems, Springer, Wien/New York, 2003.
K. Hayashi et al., Atomic Force Microscopy: Biomedical Methods and Applications, Humana Press, Totowa, New Jersey, 2003.