Biomaterials Lab., BME, OUS

Introduction

　Medical devices for apheresis therapy, bioartificial organs, and biomedical materials are the major interests in our laboratory. Apheresis therapy is designed to remove pathogenic substances in patients’ blood. It contributes to the treatments of many severe diseases such as liver failure, autoimmune diseases, and hypercholesteremia. We develop new adsorbents for more selective pathogen removal. Bioartificial organs, the hybrid-type artificial organs with cells and artificial materials, attract the attention as new treatments in the near future. We research noble bioartificial liver and bioartificial pancreas utilizing human cells in collaboration with medical researchers.

Researchs

Bioartificial organs

Bioartificial liver
Bioartificial pancreas
Cell culture system

Medical devices for apheresis therapy

Apheresis device using selective adsorbent
Apheresis device using separating membrane
Apheresis monitor

Biomaterials

Adsorbent and membrane for selective removing pathogenic substances
Biocompatible materials

Members

Professor, Shuhei Nakaji, Building No.5, 3rd floor,
　　snakaji＠bme．ous．ac．jp，Tel: +81-256-9685

Room & Devices

Laboratory 1 Building No.27, 3rd floor, Room No.314

Laboratory 2 Building No.27, 3rd floor, Room No.308

Office Building No.5, 3rd floor

　　　

Bio Safety Cabinet (SANYO, MHE-131AJ)
CO2 Incubator (SANYO, MCO-18AIC)
Bench-top Clean Bench (SANYO, MCV-710ATS)
Inverted Microscope (OLYMPUS, CKX41)
High Speed Refrigerated Centrifuge (KUBOTA, 6500）
Autoclave (HIRAYAMA, HV-50)
Automated Blood Coagulation Analyzer (SYSMEX, CA-50)
High Performance Liquid Chromatography (HITACHI, L-2000)
Plasmapheresis Monitor (KURARAY MEDICAL, KPS-8800Ce)
Apheresis Monitor (KURARAY MEDICAL, KM-8900)
Micro Plate Reader (BIO-RAD, 680)
Thermal Cycler (BIO-RAD, MyCycler)

Papers (Last five years)
【Major Publications】

H.Ikeda, N.Kobayashi, Y.Tanaka, S.Nakaji et al, A newly developed bioartificial pancreas successfully controls blood glucose in totally pancreatectomized diabetic pigs, Tissue Engineering, 12, 1799-1809, 2006

M.Narushima, N.Kobayashi, T.Okitsu, S.Nakaji et al, A human β-cell line for tranaplantation therapy to control typeⅠ diabetes. Nature Biotechnology, 23, 1274-1282, 2005

N.Kobayashi, T.Okitsu, S.Nakaji and N.Tanaka, Hybrid bioartificial liver: establishing a reversibly immortalized human hepatocyte line and developing a bioartificial liver for practical use. J Artif Organs, 6, 236-244, 2003

S.Nakaji and N.Hayashi, Bilirubin adsorption column Medisorba BL-300: Therapeutic Apheresis and Dialysis, 7, 98-103, 2003

S.Nakaji and N.Hayashi, Adsorption column for myasthenia gravis treatment: Medisorba MG-50. Therapeutic Apheresis and Dialysis, 7, 78-84, 2003